As part of Public Health Thank You Day, celebrated every year on the Monday before Thanksgiving, we’d like to honor Denise Cardo, MD, who recently retired from public service after 30 years dedicated to patient safety. Denise leaves a legacy of protecting the United States and the globe from some of our most challenging and urgent infectious disease threats. Cardo joined CDC in 1993 as a medical epidemiologist in the Hospital Infections Program (later named the Division of Healthcare Quality Promotion), and after holding several leadership positions in DHQP, she was selected as division director in 2003. Cardo is beloved